Take the Olokizumab vial or pre-filled syringe out of the refrigerator in advance: wait for approximately 30 minutes for it to warm to room temperature before preparing the injection.
Do not heat up the product.

the drug

the drug

Instructions for preparing and injecting

Instructions for preparing

Step 1

Prepare a 1-2 mL disposable hypodermic syringe, two disposable sterile needles (it is recommended to use an 18G needle to draw the drug from the vial and a 27G needle to perform a subcutaneous injection), 2 sterile alcohol wipes.

Wash your hands with warm water and soap, choose a flat, clean surface, carefully inspect the drug vial or pre-filled syringe.

The drug in a pre-filled syringe is ready for use.
Prepare the drug in a vial for use following the instructions

Step 2

Take the syringe in your right hand, remove the cap from the needle and insert the needle vertically into the center of the vial stopper so that the tip of the needle appears on the other side of the stopper.

2

Holding the syringe with your right hand, take the vial with your left hand and turn it upside down so that all the liquid collects over the stopper. Pulling the plunger of the syringe down, draw the entire contents of the vial into the syringe.

3

Join the capped thicker drawing needle with the syringe. Remove the plastic protective cap from the vial, clean the top of the rubber stopper with a sterile alcohol wipe.

1

Pull the needle out of the vial and place the cap back on it. Without removing the cap, replace it with a hypodermic needle. Dispose of the used drawing needle into the sharps container.

4

Do not perform the injection with the drawing needle as this may cause pain and damage at the injection site.

Important!

Step 3

Hold the syringe in your dominant hand over the raised area of skin at a 90 degree angle. Insert the needle into the skin with a quick, smooth thrusting motion. If there is a low amount of subcutaneous fat on the abdomen, a 45-degree angle may be used.

Do not move the needle relative to the tissue and push the plunger down slowly until the entire volume of the drug from the syringe is injected under the skin. The plunger should reach the bottom of the syringe. Wait a few seconds before removing the needle. Pull the needle out of the skin at the same angle at which it was inserted. There may be slight bleeding at the injection site. If necessary, place a sterile wipe on the injection site.

Select an injection site on the upper thighs or abdomen, at least 5 cm from the navel. If the injection is performed by a healthcare professional, other sites for subcutaneous injections may be selected. The drug should not be injected into moles, scars, lesions or indurations, areas of redness, skin hypersensitivity reactions. It is recommended to change the injection site regularly. The new injection site should be at least 2.5 cm from the previous one. You can alternate injection sites between the thighs and abdomen.

Clean the skin of the selected injection site with a new sterile alcohol wipe. Allow the injection site to dry and do not touch it prior to injection. Gently squeeze the skin around the injection site with your non-dominant hand (for example, if you are right-handed, use your left hand) and hold it firmly.

Carefully remove the cap from the hypodermic needle. Do not touch it and be careful not to stick yourself with the tip of the needle. Hold the syringe upright and flick it with your finger to make any air bubbles go to the top. Holding the syringe upright, push the plunger slowly up to expel air and excess fluid from the syringe so that the syringe plunger stops at the 0.4 mL mark. Place the syringe on the carton so that the needle stays on top of the package and does not touch other surfaces.

Dispose of used syringes in the sharps container immediately after injection. When the container is full, close it carefully and tightly and discard it in a trash can. Always use a new syringe, do not reuse syringes.

Remember!